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| Martin Lawrence | Malcolm/Big Momma | |
| Brandon T. Jackson | Trent/Charmaine | |
| Jessica Lucas | Haley | |
| Michelle Ang | Mia | |
| Portia Doubleday | Jasmine | |
| Emily Rios | Isabelle | |
| Ana Ortiz | Gail | |
| Henri Lubatti | Vlad | |
| Lorenzo Pisoni | Dmitri | |
| Tony Curran | Chirkoff | |
| Marc John Jefferies | Rembrandt | |
| Brandon Gill | Scratch | |
| Zack Mines | Delanté | |
| Trey Lindsey | TJ | |
| Ken Jeong | Mailman |
| Director |
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| Producer | Michael Green
David T. Friendly |
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| Writer | Don Rhymer
Matthew Fogel |
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| Cinematography | Anthony B. Richmond
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| Musician | David Newman
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FBI agent Malcolm Turner and his 17-year-old son, Trent, go undercover at an all-girls performing arts school after Trent witnesses a murder. Posing as Big Momma and Charmaine, they must find the murderer before he finds them. |
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