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| Mary Elizabeth Winstead | Lauren | |
| Jessica Alba | Michelle | |
| Adam Scott | Carter | |
| Jane Lynch | Dr. Judith | |
| Amy Poehler | Sondra | |
| Richard Jenkins | Hugh | |
| Catherine O'Hara | Melissa | |
| Clark Duke | Trey | |
| Adam Pally | Mark |
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A man (Scott) becomes aware that he was an unknowing former participant in a study about children of divorce, and he is sought as a participant in a follow-up study several years later. Participation in the present day has comedic results.[4] His younger brother (Duke) has a wedding which brings his divorced parents back together, causing lots of friction.[4] |
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