When a virus leaks from a top-secret facility, turning all resident researchers into ravenous zombies and their lab animals into mutated hounds from hell, the government sends in an elite military task force to contain the outbreak. Alice and Rain are charged with leading the mission. But they only have three hours before the pathogen becomes airborne and infects the world.

As the city is locked down under quarantine, Alice joins a small band of elite soldiers, enlisted to rescue the missing daughter of the creator of the mutating T-virus. It's a heart-pounding race against time as the group faces off against hordes of blood- thirsty zombies, stealthy Lickers, mutant canines and the most sinister foe yet.

Years after the Racoon City catastrophe, survivors travel across the Nevada desert, hoping to make it to Alaska. Alice joins the caravan and their fight against hordes of zombies and the evil Umbrella Corp.