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| William Hurt | Professor Eddie Jessup | |
| Blair Brown | Emily Jessup | |
| Bob Balaban | Arthur Rosenberg | |
| Charles Haid | Mason Parrish | |
| Thaao Penghlis | Eduardo Eccheverria | |
| Miguel Godreau | Primal Man | |
| Dori Brenner | Sylvia Rosenberg | |
| Peter Brandon | Alan Hobart | |
| Charles White-Eagle | The Brujo, Hindris Indian | |
| Drew Barrymore | Margaret Jessup |
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| Producer | Stuart Baird
Daniel Melnick |
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| Writer | Paddy Chayefsky
Sidney Aaron |
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| Cinematography | Jordan Cronenweth
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| Musician | John Corigliano
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Research scientist Eddie Jessup (William Hurt) believes other states of consciousness are as real as everyday reality. Using sensory deprivation, then adding powerful, hallucinogenic drugs, he explores these altered states...and endures experiences that make madness seem a blessing. |
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