Marcus Burnett is a hen-pecked family man. Mike Lowry is a foot-loose and fancy free ladies' man. Both are Miami policemen, and both have 72 hours to reclaim a consignment of drugs stolen from under their station's nose. To complicate matters, in order to get the assistance of the sole witness to a murder, they have to pretend to be each other.

Martin Lawrence and Will Smith reunite as out-of-control trash-talking buddy cops Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force. Bullets fly, cars crash, and laughs explode as they pursue a whacked-out drug lord from the streets of Miami to the barrios of Cuba. But the real fireworks result when Lawrence discovers that playboy Smith is secretly romancing his sexy sister Syd.