Alice Abernathy (Milla Jovovich) continues her battle against The Umbrella Corporation's hostile AI system The Red Queen (Megan Charpentier) with the help of her friends Jill Valentine (Sienna Guillory), Leon Scott Kennedy (Johann Urb), Ada Wong (Li Bingbing), and her daughter Becky (Aryanna Engineer), while continuing an uneasy alliance with the former head of Umbrella, Albert Wesker (Shawn Roberts). Along the way, they will reconnect with former comrades Chris Redfield (Wentworth Miller), Claire Redfield (Ali Larter), and Kmart (Spencer Locke). Their epic battle will lead them back to where it all began in the dark mansion built by Umbrella founder Lord Ozwell E. Spencer and the deep underground research and development center known as The Hive, where The Red Queen plots total destruction over the human race.