American Assassin follows the rise of Mitch Rapp (Dylan O'Brien), a CIA black-ops recruit under the instruction of Cold War veteran Stan Hurley (Michael Keaton). The pair is then enlisted by CIA Deputy Director Irene Kennedy (Sanaa Lathan) to investigate a wave of apparently random attacks on both military and civilan targets. Together, the three discover a pattern in the violence, leading them to a joint mission with a lethal Turkish agent (Shiva Negar) to stop a mysterious operative (Taylor Kitsch) intent on settling a personal and professional vendetta that could have cataclysmic results.