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| Robert Downey Jr. | Sherlock Holmes | |
| Jude Law | Dr. John Watson | |
| Noomi Rapace | Madam Simza Heron | |
| Rachel McAdams | Irene Adler | |
| Jared Harris | Professor James Moriarty | |
| Stephen Fry | Mycroft Holmes | |
| Paul Anderson | Colonel Sebastian Moran | |
| Kelly Reilly | Mary Watson | |
| Geraldine James | Mrs. Hudson | |
| Eddie Marsan | Inspector Lestrade | |
| William Houston | Constable Clark | |
| Wolf Kahler | Doctor Hoffmanstahl | |
| Iain Mitchell | Auctioneer | |
| Jack Laskey | Carruthers | |
| Patricia Slater | Shush Club Maitre D' | |
| Karima Adebibe | Shush Club Maitre D' | |
| Richard Cunningham | Businessman | |
| Marcus Shakesheff | Hashisheen | |
| Mark Sheals | Cock Fight Referee | |
| George Taylor | University Student |
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Robert Downey Jr. reprises his role as the world's most famous detective, Sherlock Holmes, and Jude Law returns as his friend and colleague, Dr. Watson, in "Sherlock Holmes: A Game of Shadows." Holmes has always been the smartest man in the room…until now. Criminal mastermind at large Professor James Moriarty (Jared Harris) is not only Holmes' intellectual equal, but he has a capacity for evil that may give him a deadly advantage. Now, as a rash of murder and mayhem breaks out across the globe, only Holmes and Watson can stop the cunning Moriaty from completing his ominous plan and altering the course of history. |
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