The search for Ashley puts Magnus and her allies in the path of Kate Freelander (Agam Darshi), a con artist with ties to the Cabal who divulges the location of a secret facility

Furious at being duped into a trap, Magnus (AMANDA TAPPING) takes on Kate (AGAM DARSHI), demanding information and complete access to her Cabal contacts. The Cabal’s true agenda is revealed and Magnus realizes that they are not only holding Ashley (EMILIE ULLERUP) as ransom to obtain complete control of the Sanctuary Network, but turning her into the ultimate weapon. Now transformed into a Super Abnormal with devastating powers, Ashley and her newly cloned fighters begin their onslaught, destroying Sanctuaries in cities around the world. Tesla (JONATHON YOUNG) and Henry (RYAN ROBBINS) attempt to create a weapon that can stop the attacks…without killing Ashley. As the team prepares to defend the Sanctuary with Tesla’s new weapon, Magnus must come to the realization that they may not be able to stop the Cabal’s attacks without harming Ashley. She realizes she might have to choose between saving her only daughter, or losing the Sanctuary and all the lives and secrets within it.

With chaos all around them, the team must come to terms with how to rebuild after the Cabal’s attacks. Magnus takes a methodical approach to prove Ashley is still alive, while Will and Henry take on the daunting task of processing the hundreds of Abnormals who now seek refuge at the Sanctuary.

A superhero is trapped by Magnus, and his lack of finesse affects the team's work. Elsewhere, Will and Declan go on the search for a creature that's loose in the city, after the discovery of an eggshell.

A disoriented Magnus wakes up to find the Sanctuary in ruins and the entire city decimated, with no memory of how the devastation occurred. While surveying the destruction, she is attacked by an inhuman creature but saved by two armed men who stun her and take her to an abandoned warehouse. After being hosed down and left shivering and exhausted, Magnus fears the worst when a battle-scarred figure enters the room.

Dr. Helen Magnus fights to save the life of one of the Sanctuary’s research scientists who was viciously attacked by a seemingly docile Abnormal. Baffled by the creature’s uncharacteristic behavior, Henry tries to figure out what, or who, caused the domesticated Abnormal to react so violently.

Will goes up against the heads of the Sanctuary Network to defend Magnus who is charged with a shocking murder. But as the evidence stacks up against her, even Will has trouble finding a way to convincingly defend her innocence.

Magnus and Will are called to make a straightforward retrieval of a rare Abnormal off the coast of Louisiana. With a commissioned helicopter, the retrieval is successful and their cargo securely on board. But as the pair starts heading back to the mainland, something causes the unusual sea creature to break loose. Unable to control the Abnormal and the helicopter simultaneously, Magnus and Will make a crash landing and find themselves entangled in guy wire, precariously dangling over an abandoned oil bore well several feet above the water in the middle of the Gulf of Mexico. With the Abnormal nowhere to be found, Magnus concludes it has made its getaway into the depths of the water. But their solitude doesn’t last long. Not only does the Abnormal return, it’s even angrier than before. And Magnus and Will quickly learn they must escape or become its next victim.

Magnus is reunited with an old friend, Jimmy who is transporting a valuable elemental Abnormal to the Sanctuary for safety. But an underground mob accustomed to cashing in on the Abnormal black market, tracks down Jimmy and his valuable cargo before the delivery is complete. Magnus and Jimmy find themselves in a dangerous shootout, determined to save the Abnormal. Will, Kate and Henry are quick on the scene as backup. Kate proves her worth when she manages to get Jimmy and the Abnormal to safety. But not before taking a shot from one of the mobsters herself. Hiding out in an abandoned, derelict motel room until the immediate danger of the mob passes, Jimmy tends to Kate’s gunshot wound. With little to do but talk and wait for Magnus to find them, Jimmy and Kate discover an unexpected common history.

Magnus and Will investigate a number of inexplicable teenage disappearances. The common denominator in the case seems to be that they all recently spent time at an exclusive rehab clinic in Mexico. Paying a visit to the clinic, Magnus and Will are surprised to meet the program’s director…none other than a disguised Nikola Tesla, one of the original Five. Tesla portentously explains he has been working on a treatment that cures the teens of their addictions in merely a week. Magnus and Will know Tesla has an ulterior motive and press him to disclose the real purpose for the clinic. Unable to hold back his excitement, Tesla reveals he is actually turning his patients into Vampires. Tesla’s treatment is designed to create a time-release of the Vampire gene, evolving his unsuspecting patients into Vampires over a 30-year period. But when one of his patients discovers the formula to speed up the process, they find themselves up against a powerful and determined group of new Vampires. Unless they can be stopped, Magnus fears Tesla may have unleashed the resurrection of the deadliest race of Abnormals ever to roam the Earth.

The team rescues the occupants of a sinking ship off the coast of South Africa and teleport them to the Sanctuary. However, Magnus suspects Druitt of murdering one of the passengers during the rescue.

The team investigate a murder in Mumbai, and find a connection to the ancient cult of Kali, whose followers can foretell disaster. However, Will falls ill and disappears, and is somehow linked to the mystery.

Will begins to experience strange visions that are connected to the Cult of Kali. Magnus has difficulty with finding the solution to their problems.