In Abbot and Costello: Africa Screams, the boys are a pair of booksellers who find themselves deep in the wilds of Africa when they purport themselves to be knowledgeable of the country. In search of diamonds and led by a beautiful woman named Diana, Abbott and Costello are spurred on by promises of sharing the elusive loot if they can find it. Along the way they find themselves in sticky situations that involve lion tamers, gigantic gorillas, and an unruly river. Wil the bumbling pair survive their encounters with the wildlife? Will they find the diamonds and get their share of riches?